工具 API

alphagenome_predictor

Predict variant effects on gene regulation using Google DeepMind's AlphaGenome. ⚠️ PREREQUISITE: Use the 'think' tool FIRST to plan your analysis strategy! AlphaGenome provides state-of-the-art predictions for how genetic variants affect gene regulation, including: - Gene expression changes (RNA-seq) - Chromatin accessibility impacts (ATAC-seq, DNase-seq) - Splicing alterations - Promoter activity changes (CAGE) This tool requires: 1. AlphaGenome to be installed (see error message for instructions) 2. An API key from https://deepmind.google.com/science/alphagenome API Key Options: - Provide directly via the api_key parameter - Or set ALPHAGENOME_API_KEY environment variable Example usage: - Predict regulatory effects of BRAF V600E mutation: chr7:140753336 A>T - Assess non-coding variant impact on gene expression - Evaluate promoter variants in specific tissues Note: This is an optional tool that enhances variant interpretation with AI predictions. Standard annotations remain available via variant_getter.